Quantile-Dependent Expressivity of Serum Uric Acid Concentrations

Figure 3

Precision medicine perspective of genotype-specific uric acid differences (histogram inserts) vs. quantile-dependent expressivity perspective (line graphs showing larger genetic effect size when average uric acid concentrations were high) for (a) Das Gupta et al.’s [37] 2018 report on the uric acid difference between gout patients and healthy controls by SLC2A9 rs11722228 genotypes; (b) Yang et al.’s [42] 2014 report on the uric acid difference between males and females by ABCG2 rs2231142 genotypes; (c) Lin et al.’s [43] report on the uric acid difference between males and females by ABCG2 rs2231142 genotypes; (d) Lin et al.’s [43] 2020 report on the uric acid difference between males and females by rs13120819 genotypes located 5 of ABCG2; (e) Sarzynski et al.’s [47] 2012 report on the uric acid difference before and after 29 kg weight loss following bariatric surgery by SLC2A9 rs13113918 genotypes; (f) Cheng et al.’s [48] 2017 report on the uric acid difference between obese and nonobese women by ABCG2 rs2231142 genotypes.