Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer

Table 3

Univariate and multivariate Cox regression analyses of various prognostic parameters of overall survival in patients with breast cancer.

Parameters	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age (years) (≥60 vs.<60)	1.912 (1.390-2.631)	<0.001	2.249 (1.219-4.148)	0.009
Menopause status
Peri vs. pre	0.369 (0.049-2.761)	0.332	0.822 (0.108-6.284)	0.850
Post vs. pre	2.105 (1.281-3.459)	0.003	1.228 (0.585-2.581)	0.587
T classification
T2 vs. T1	1.331 (0.887-1.998)	0.167	1.198 (0.632-2.271)	0.580
T3 vs. T1	1.578 (0.936-2.658)	0.087	1.484 (0.605-3.643)	0.389
T4 vs. T1	3.967 (2.138-7.362)	<0.001	1.721 (0.534-5.547)	0.363
N classification
N1 vs. N0	1.874 (1.273-2.758)	0.001	1.231 (0.638-2.372)	0.535
N2 vs. N0	2.719 (1.627-4.545)	<0.001	3.195 (0.974-10.478)	0.055
N3 vs. N0	4.081 (2.256-7.381)	<0.001	4.463 (1.401-14.222)	0.011
M classification (M1 vs. M0)	4.784 (2.858-8.007)	<0.001	3.504 (1.393-8.815)	0.008
TNM stage (III-IV vs. I-II)	2.605 (1.869-3.630)	<0.001	1.187 (0.415-3.391)	0.749
Margin status
Close vs. negative	1.876 (0.818-4.303)	0.137	2.740 (1.028-7.306)	0.044
Positive vs. negative	1.951 (1.186-3.212)	0.009	0.647 (0.296-1.417)	0.277
ZNF385B (low vs. high)	2.021 (1.465-2.788)	<0.001	3.040 (1.894-4.877)	<0.001

HR: hazard ratio; CI: confidence interval; M: metastasis; N: node; T: tumor.