Downregulated mRNA Expression of ZNF385B Is an Independent Predictor of Breast Cancer

Table 4

Univariate and multivariate Cox regression analyses of various prognostic parameters of relapse-free survival in patients with breast cancer.

Parameters	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
ER (negative vs. positive)	1.643 (1.062-2.542)	0.026	1.340 (0.611-2.937)	0.465
PR (negative vs. positive)	1.641 (1.088-2.477)	0.018	1.402 (0.657-2.994)	0.383
T classification
T2 vs. T1	1.635 (0.944-2.833)	0.079	1.235 (0.631-2.417)	0.537
T3 vs. T1	2.524 (1.321-4.824)	0.005	1.267 (0.487-3.299)	0.628
T4 vs. T1	6.72 (2.885-15.656)	<0.001	2.013 (0.553-7.321)	0.288
N classification
N1 vs. N0	2.255 (1.357-3.748)	0.002	1.560 (0.822-2.958)	0.173
N2 vs. N0	2.642 (1.326-5.264)	0.006	2.741 (0.749-10.035)	0.128
N3 vs. N0	6.54 (3.415-12.524)	<0.001	7.106 (1.998-25.278)	0.002
M classification (M1 vs. M0)	4.024 (1.742-9.292)	0.001	1.294 (0.442-3.784)	0.638
TNM stage (III-IV vs. I-II)	3.190 (2.106-4.831)	<0.001	1.147 (0.375-3.508)	0.809
Margin status
Close vs. negative	2.228 (0.966-5.141)	0.060	3.229 (1.319-7.905)	0.010
Positive vs. negative	2.453 (1.441-4.177)	0.001	1.738 (0.836-3.611)	0.139
ZNF385B (low vs. high)	2.227 (1.480-3.349)	<0.001	2.609 (1.531-4.449)	<0.001

CI: confidence interval; ER: estrogen receptor; HR: hazard ratio; M: metastasis; N: node; PR: progesterone receptor; T: tumor.