Review Article
Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans
Table 1
Summary of rDNA methylation in selected cancer cases.
| Disease | rDNA region | Methylation status | References |
| Late-stage ovarian cancer | 18S and 28S rDNA | Hypermethylation | Chan et al. [38] | Breast cancer | 18S, 5.8S, and 28S rDNA | Hypermethylation | Yan et al. [39] | Primary endometrial carcinoma | 5.8S and 28S rDNA | Hypermethylation | Powell et al. [40] | Liver cancer | IGS | Hypomethylation | Zhang et al. [30] | Lung cancer | Prostate cancer | Colon cancer | Cervical cancer (cervical intraepithelial neoplasia (CIN)) | Promoter | Hypomethylation | Zhou et al. [31] | Hepatocellular carcinomas | Promoter | Hypomethylation | Ghoshal et al. [2] | Primary oral squamous cell carcinoma (OSCC) | Promoter | No significant difference between cancer patients and control samples | Ha et al. [45] | Prostate cancer | Promoter | DNA methylation level remained unchanged | Uemura et al. [15] |
|
|