IL1RN and PRRX1 as a Prognostic Biomarker Correlated with Immune Infiltrates in Colorectal Cancer: Evidence from Bioinformatic Analysis

Table 1

Functional roles of 15 seed genes.

Gene symbol	Function
IL1RN	Regulating various immune as well as inflammatory reactions related to interleukin 1, specifically at the early stage of infectious or inflammatory conditions.
GALNT12	Facilitating the catalyzation of the transition of N- acetylgalactosamine from UDP-GalNAc to the surface acceptor at the first stage of O-linked protein glycosylation.
ADH6	Codifying for class V alcohol dehydrogenase belonging to the alcohol dehydrogenase family.
SCN7A	Encoding one of the many voltage-gated sodium channel proteins.
CXCL1	Acting as a chelating agent for neutrophils in the inflammatory process.
FGF18	Riching in functions regulating cell mitosis and maintaining cell survival activity, engaged in extensive biological processes including growth and invasion of diverse neoplasms.
SOX9	Intervening in the differentiation procedure of chondrocytes, and in concert with SF1, involved in the regulation of the transcribing of the AMH gene.
ACACB	Involving a pivotal step in the uptake and oxidation of fatty acids in mitochondria due to a mechanism involving inhibition of the ability of carnitine-palmitoyl-CoA transferase I to control the oxidation of fatty acids.
PRRX1	Enhancing the binding potential of serum response factors to induce cell growth and differentiation.
MZB1	Involved in positive regulation of cell population proliferation.
SLC22A3	Involved in the removal of numerous internal sources of small organic cations as well as various pharmaceutical substances or environmental toxins.
LY6E	Encoding a protein broadly engaged in regulating tumorigenesis and modulating immune function, which is located on the cell surface and supplies the anchor point for GPI.
IFITM2	The protein encoded by this gene restricts cellular entry by diverse viral pathogens.
GDPD3	Enabling phosphoric diester hydrolase activity. Involved in N-acylethanolamine metabolic process.
CNNM4	Encoding a protein that assists in the transport of metal ions.