Three Prognostic Biomarkers Correlate with Immune Checkpoint Blockade Response in Bladder Urothelial Carcinoma

Figure 5

Evaluation of the association between three prognosis-related key genes and clinical factors. Expression of three key prognosis-related genes based on different sample types, according to (a)–(c) histological subtypes, (d)–(f) molecular subtypes, and (g)–(i) TP53 mutation status. (j)–(l) Associations between expression of three prognosis-related genes and immune subtypes across BLCA via TISIDB database: (j) AURKA, (k) BIRC5, and (l) CKS1B. Act_CD8: activated CD8 T cell; Tcm_CD8: central memory CD8 T cell; Tem_CD8: effector memory CD8 T; C1: wound healing; C2: IFN-γ dominant; C3: inflammatory; C4: lymphocyte depleted; C5: immunologically quiet; C6: TGF-β dominant. Kruskal–Wallis test was used to evaluate the statistical significance of differential expression.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)