Three Prognostic Biomarkers Correlate with Immune Checkpoint Blockade Response in Bladder Urothelial Carcinoma

Table 1

Confirmation of the associations of three hub genes with prognosis in three different databases. PROGgeneV2, PrognoScan, and OSblca databases were used to confirm the prognostic value of three hub genes in BLCA. HR: hazard ratio.

Database	Dataset	Gene	Endpoint	value	HR [95% CI low-CI up]
PROGgenesV2	GSE13507	AURKA	OS	0.00135	1.39 [1.14-1.7]
	GSE13507	BIRC5	OS	0.01299	1.94 [1.15-3.26]
	GSE13507	CKS1B	OS	0.03256	1.24 [1.02-1.5]
	GSE19915	BIRC5	OS	0.00009	2.62 [1.62-4.24]
PrognoScan	GSE13507_ILMN_1680955	AURKA	OS	0.00128	1.39 [1.14-1.70]
	GSE13507_ILMN_1680955	AURKA	DFS	0.00011	1.91 [1.40-2.62]
	GSE5287_210334_x_at	BIRC5	OS	0.00560	7.68 [2.55-23.14]
	GSE5287_202095_s_at	BIRC5	OS	0.00183	2.43 [1.35-4.38]
	GSE13507_ILMN_1710082	BIRC5	OS	0.00179	1.94 [1.15-3.26]
	GSE13507_ILMN_1710082	BIRC5	DFS	0.00077	3.22 [1.65-6.31]
	GSE13507_ILMN_1719256	CKS1B	DFS	0.04721	1.56 [1.17-2.08]
OSblca	GSE13507_ILMN_1710082	BIRC5	OS	0.01880	1.837 [1.1059-3.0515]
	GSE13507_ILMN_1680955	AURKA	OS	0.00400	2.1412 [1.2742-3.5983]
	GSE19915	BIRC5	DSS	0.00030	4.4378 [1.9813-9.9398]
	GSE32548_ILMN_2349459	BIRC5	OS	0.04900	2.2344 [1.0036-4.9749]
	GSE48507_ILMN_2349459	BIRC5	OS	0.00400	2.5862 [1.3551-4.936]
	GSE48075_ILMN_1803124	BIRC5	OS	0.00900	2.3966 [1.2444-4.6154]
	GSE32548_ILMN_1719256	CKS1B	OS	0.03500	2.3667 [1.026-5.2711]
	GSE32548_ILMN_2041046	CKS1B	OS	0.00790	2.9205 [1.3245-6.4394]