International Journal of Genomics

Research Article

Three Prognostic Biomarkers Correlate with Immune Checkpoint Blockade Response in Bladder Urothelial Carcinoma

Table 2

Relationships of three prognostic genes with clinical characteristics. Clinical characteristics included age, histological subtype (papillary or nonpapillary tumor), molecular subtype (luminal papillary, luminal infiltrated, luminal, basal squamous, and neuronal), nodal metastasis status (N0: no regional lymph node metastasis; N1: metastases in 1–3 axillary lymph nodes; N2: metastases in 4–9 axillary lymph nodes; N3: metastases in 10 or more axillary lymph nodes), sample type, smoking, cancer stage, and TP53 mutation status.
Gene symbolClinical characteristicComparison value
AURKAAgeNormal-vs-age (41-60 Y)4.00E-15
Normal-vs-age (61-80 Y)<1E-12
Normal-vs-age (81-100Y)7.10E-10
BIRC5AgeNormal-vs-age (41-60 Y)1.82E-10
Normal-vs-age (61-80 Y)3.99991E-12
Normal-vs-age (81-100Y)2.40E-09
CKS1BAgeNormal-vs-age (41-60 Y)8.88E-16
Normal-vs-age (61-80 Y)1.62E-12
Normal-vs-age (81-100Y)2.617E-07
AURKAHistological subtypesNormal-vs-papillary tumors6.55E-15
Normal-vs-nonpapillary tumors<1E-12
Papillary tumors-vs-nonpapillary tumors3.00E-03
BIRC5Histological subtypesNormal-vs-papillary tumors6.40E-07
Normal-vs-nonpapillary tumors8.40E-10
Papillary tumors-vs-nonpapillary tumors1.10E-03
CKS1BHistological subtypesNormal-vs-papillary tumors1.77E-04
Normal-vs-nonpapillary tumors3.27E-08
Papillary tumors-vs-nonpapillary tumors2.38E-04
AURKAMolecular subtypesNormal-vs-neuronal1.54E-06
Normal-vs-basal squamous<1E-12
Normal-vs-luminal2.26E-10
Normal-vs-luminal_infiltrated1.49E-11
Normal-vs-luminal_papillary1.67E-12
Neuronal-vs-luminal1.05E-02
Neuronal-vs-luminal_infiltrated2.48E-03
Neuronal-vs-luminal_papillary6.00E-03
Basal squamous-vs-luminal1.66E-05
Basal squamous-vs-luminal_infiltrated8.65E-12
Basal squamous-vs-luminal_papillary1.11E-09
BIRC5Molecular subtypesNormal-vs-neuronal3.20E-07
Normal-vs-basal squamous1.65E-12
Normal-vs-luminal2.93E-07
Normal-vs-luminal_infiltrated4.66E-07
Normal-vs-luminal_papillary1.15E-08
Neuronal-vs-basal squamous3.40E-03
Neuronal-vs-luminal9.81E-05
Neuronal-vs-luminal_infiltrated4.18E-05
Neuronal-vs-luminal_papillary9.99E-05
Basal squamous-vs-luminal3.10E-06
Basal squamous-vs-luminal_infiltrated1.03E-11
Basal squamous-vs-luminal_papillary1.36E-08
CKS1BMolecular subtypesNormal-vs-neuronal9.74E-07
Normal-vs-basal squamous1.62E-12
Normal-vs-luminal2.40E-08
Normal-vs-luminal_infiltrated5.97E-11
Normal-vs-luminal_papillary4.44E-15
Neuronal-vs-basal squamous4.57E-02
Neuronal-vs-luminal1.74E-03
Neuronal-vs-luminal_infiltrated1.46E-03
Neuronal-vs-luminal_papillary9.79E-04
Basal squamous-vs-luminal9.60E-04
Basal squamous-vs-luminal_infiltrated9.92E-05
Basal squamous-vs-luminal_papillary2.26E-07
AURKANodal metastasis statusNormal-vs-N01.62E-12
Normal-vs-N11.69E-12
Normal-vs-N22.22E-12
Normal-vs-N31.25E-10
BIRC5Nodal metastasis statusNormal-vs-N01.34E-11
Normal-vs-N11.69E-10
Normal-vs-N28.57E-09
Normal-vs-N37.04E-03
N1-vs-N22.50E-02
CKS1BNodal metastasis statusNormal-vs-N01.62E-12
Normal-vs-N11.04E-09
Normal-vs-N21.63E-12
Normal-vs-N38.60E-04
N0-vs-N14.35E-02
N1-vs-N21.70E-02
N2-vs-N32.42E-02
AURKASample typesNormal-vs-primary1.62E-12
BIRC5Normal-vs-primary5.35E-11
CKS1BNormal-vs-primary1.62E-12
AURKASmoking habitNormal-vs-nonsmoker1.24E-14
Normal-vs-smoker1.63E-12
Normal-vs-reformed smoker1<1E-12
Normal-vs-reformed smoker21.33E-15
Nonsmoker-vs-reformed smoker18.60E-03
Nonsmoker-vs-reformed smoker29.46E-03
BIRC5Smoking habitNormal-vs-nonsmoker1.82E-09
Normal-vs-smoker2.35E-10
Normal-vs-reformed smoker13.83E-12
Normal-vs-reformed smoker23.34E-12
CKS1BSmoking habitNormal-vs-nonsmoker1.63E-12
Normal-vs-smoker5.55E-16
Normal-vs-reformed smoker1<1E-12
Normal-vs-reformed smoker21.62E-12
AURKACancer stageNormal-vs-stage21.62E-12
Normal-vs-stage31.62E-12
Normal-vs-stage41.62E-12
BIRC5Cancer stageNormal-vs-stage21.53E-10
Normal-vs-stage33.81E-13
Normal-vs-stage47.86E-12
CKS1BCancer stageNormal-vs-stage2<1E-12
Normal-vs-stage3<1E-12
Normal-vs-stage41.62E-12
AURKATP53 mutation statusNormal-vs-TP53-mutant1.62E-12
Normal-vs-TP53-nonmutant3.63E-13
TP53-mutant-vs-TP53-nonmutant3.80E-12
BIRC5TP53 mutation statusNormal-vs-TP53-mutant1.63E-12
Normal-vs-TP53-nonmutant8.02E-09
TP53-mutant-vs-TP53-nonmutant7.83E-08
CKS1BTP53 mutation statusNormal-vs-TP53-mutant1.62E-12
Normal-vs-TP53-nonmutant8.44E-15
TP53-mutant-vs-TP53-nonmutant2.20E-12