Research Article
A Novel Hypoxia-Related Gene Signature with Strong Predicting Ability in Non-Small-Cell Lung Cancer Identified by Comprehensive Profiling
Table 3
Univariate and multivariate analyses of the overall survival in TCGA dataset.
| | Row names | Single coefficient | HR (95% CI for HR) | Wald test | Single | Single value | Multicoefficient | HR | Multi | Multi value |
| | ADM | -0.0026 | 1 (0.91-1.1) | 0 | -0.054 | 0.96 | NA | NA | NA | NA | | Age | 0.31 | 1.4 (1-1.9) | 4.2 | 2 | 0.042 | 0.3 | 1.4 (1-1.8) | 2 | 0.051 | | BHLHE40 | 0.22 | 1.3 (1.1-1.5) | 8.5 | 2.9 | 0.0035 | NA | NA | NA | NA | | BIRC5 | -0.012 | 0.99 (0.86-1.1) | 0.03 | -0.18 | 0.85 | NA | NA | NA | NA | | C11orf86 | 0.043 | 1 (0.97-1.1) | 1.3 | 1.1 | 0.26 | NA | NA | NA | NA | | C1QL1 | -0.029 | 0.97 (0.91-1) | 0.7 | -0.84 | 0.4 | NA | NA | NA | NA | | CCDC85A | 0.088 | 1.1 (1-1.2) | 4.2 | 2 | 0.041 | NA | NA | NA | NA | | CCNA2 | -0.019 | 0.98 (0.85-1.1) | 0.07 | -0.26 | 0.79 | NA | NA | NA | NA | | CCND3 | 0.12 | 1.1 (0.97-1.3) | 2.5 | 1.6 | 0.12 | NA | NA | NA | NA | | CNKSR3 | -0.015 | 0.98 (0.86-1.1) | 0.05 | -0.21 | 0.83 | NA | NA | NA | NA | | DGAT2 | 0.096 | 1.1 (1-1.2) | 3.9 | 2 | 0.049 | NA | NA | NA | NA | | DKK1 | 0.0076 | 1 (0.95-1.1) | 0.06 | 0.25 | 0.8 | NA | NA | NA | NA | | DKK3 | -0.0016 | 1 (0.89-1.1) | 0 | -0.027 | 0.98 | NA | NA | NA | NA | | ETV1 | 0.031 | 1 (0.94-1.1) | 0.46 | 0.68 | 0.5 | NA | NA | NA | NA | | FAM160A1 | 0.058 | 1.1 (0.94-1.2) | 0.95 | 0.98 | 0.33 | NA | NA | NA | NA | | FAM81A | 0.05 | 1.1 (0.95-1.2) | 0.94 | 0.97 | 0.33 | NA | NA | NA | NA | | HECA | 0.13 | 1.1 (0.96-1.4) | 2.2 | 1.5 | 0.14 | NA | NA | NA | NA | | HMGA2 | -0.0095 | 0.99 (0.94-1) | 0.14 | -0.38 | 0.7 | NA | NA | NA | NA | | HNRNPA2B1 | 0.089 | 1.1 (0.88-1.4) | 0.67 | 0.82 | 0.41 | NA | NA | NA | NA | | HOXC8 | 0.0016 | 1 (0.94-1.1) | 0 | 0.05 | 0.96 | NA | NA | NA | NA | | ISOC1 | 0.041 | 1 (0.88-1.2) | 0.23 | 0.48 | 0.63 | NA | NA | NA | NA | | KDM7A | 0.063 | 1.1 (0.91-1.3) | 0.59 | 0.77 | 0.44 | NA | NA | NA | NA | | LPCAT1 | 0.15 | 1.2 (1-1.3) | 8.3 | 2.9 | 0.004 | 0.11 | 1.1 (0.99-1.2) | 1.9 | 0.062 | | NECTIN1 | -0.02 | 0.98 (0.89-1.1) | 0.16 | -0.4 | 0.69 | NA | NA | NA | NA | | PAM | 0.1 | 1.1 (0.95-1.3) | 1.7 | 1.3 | 0.19 | NA | NA | NA | NA | | PEA15 | 0.17 | 1.2 (0.99-1.4) | 3.4 | 1.8 | 0.065 | NA | NA | NA | NA | | PPIH | 0.053 | 1.1 (0.88-1.3) | 0.34 | 0.58 | 0.56 | NA | NA | NA | NA | | PPP1R3B | 0.04 | 1 (0.91-1.2) | 0.35 | 0.59 | 0.56 | NA | NA | NA | NA | | PRMT3 | 0.068 | 1.1 (0.91-1.3) | 0.63 | 0.8 | 0.43 | NA | NA | NA | NA | | PTPRE | 0.17 | 1.2 (1-1.4) | 5.9 | 2.4 | 0.015 | NA | NA | NA | NA | | RASGEF1B | 0.094 | 1.1 (0.97-1.2) | 2.3 | 1.5 | 0.13 | NA | NA | NA | NA | | SERPINE1 | 0.15 | 1.2 (1.1-1.3) | 11 | 3.4 | 8e-04 | 0.12 | 1.1 (1-1.2) | 2.5 | 0.012 | | Sex | -0.19 | 0.83 (0.6-1.1) | 1.3 | -1.2 | 0.25 | NA | NA | NA | NA | | SLC12A2 | 0.0078 | 1 (0.89-1.1) | 0.02 | 0.13 | 0.9 | NA | NA | NA | NA | | SNAP25 | 0.069 | 1.1 (0.99-1.2) | 3.1 | 1.8 | 0.078 | NA | NA | NA | NA | | Stage | 0.3 | 1.3 (1.1-1.7) | 6.6 | 2.6 | 0.01 | 0.38 | 1.5 (1.2-1.8) | 3.2 | 0.0015 | | Status | 21 | (0-Inf) | 0 | 0.012 | 0.99 | NA | NA | NA | NA | | STC2 | 0.098 | 1.1 (1-1.2) | 4.7 | 2.2 | 0.03 | 0.11 | 1.1 (1-1.2) | 2.4 | 0.014 | | TGFBI | 0.071 | 1.1 (0.98-1.2) | 2.4 | 1.6 | 0.12 | NA | NA | NA | NA | | TMEM132B | -0.016 | 0.98 (0.91-1.1) | 0.19 | -0.43 | 0.66 | NA | NA | NA | NA | | WSB1 | 0.13 | 1.1 (0.97-1.3) | 2.4 | 1.5 | 0.12 | NA | NA | NA | NA | | ZWILCH | -0.034 | 0.97 (0.81-1.2) | 0.14 | -0.37 | 0.71 | NA | NA | NA | NA |
|
|
