Early Breast Cancer Evolution by Autosomal Broad Copy Number Alterations

Figure 4

Initial two events in most breast cancer patients appear to be 1qG and 16qL. (a) Frequency of gains (greater than 0 and green) and losses (less than 0 and red) of patients, with 1 to 2 autosomal broad CNAs (14 patients), for each SNP location on the Affymetrix SNP6.0 Microarray. (b) Frequency of patients with 1qG (cyan) and 16qL (red) by number of autosomal broad CNAs. (c) Frequency of somatic mutations for any somatic mutation present in over 10% of patients in the subset of patients, with 1 to 2 autosomal broad CNAs (14 patients). (d) The fewest structural variation events required for a full arm centromere recombination-based alteration to create a 1qG and 16qL in a normal breast cell.

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