HMOX1 Attenuates the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib via Modulating the Expression of ABC Transporters

Figure 6

Effects of HMOX1 on the sensitivity of HCC cells to sorafenib. (a) The relative mRNA expression of HMOX1 in Huh7-SR and HepG2-SR cells after scrambled siRNA (si-NC) or HMOX1 siRNA (si-HMOX1) transfection. (b) The relative viability of scrambled siRNA (si-NC) or HMOX1 siRNA- (si-HMOX1-) transfected Huh7-SR cells after being treated by sorafenib was determined by MTT assay. (c) The relative viability of scrambled siRNA (si-NC) or HMOX1 siRNA- (si-HMOX1-) transfected HepG2-SR cells after being treated by sorafenib was determined by MTT assay. (d) The relative mRNA expression of HMOX1 in Huh7-SR and HepG2-SR cells after pcDNA3.1 or pcDNA3.1-HMOX1 transfection was determined by qRT-PCR. (e) The relative viability of pcDNA3.1 or pcDNA3.1-HMOX1 transfection-transfected Huh7-SR cells after being treated by sorafenib was determined by MTT assay. (f) The relative viability of scrambled pcDNA3.1 or pcDNA3.1-HMOX1 transfection-transfected HepG2-SR cells treated by sorafenib was measured by MTT assay. . .

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