HMOX1 Attenuates the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib via Modulating the Expression of ABC Transporters

<div>ABCA6, ABCB1, ABCC1, and ABCG2 expression was upregulated in the sorafenib-resistant HCC cell lines. (a, b) Relative mRNA expression of ABCA6 in Huh7, Huh7-SR, HepG2, or HepG2-SR cells. (c, d) Relative mRNA expression of ABCB1 in Huh7 and Hun7-SR cells. (e, f) Relative mRNA expression of ABCC1 in Huh7, Huh7-SR, HepG2, or HepG2-SR cells. (g, h) Relative mRNA expression of ABCG2 in Huh7, Huh7-SR, HepG2, or HepG2-SR. <span class="nowrap"><svg height="8.8423pt" id="M15" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 32.2343 8.8423" width="32.2343pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M822 650H589L583 622C660 617 677 607 674 561C672 534 664 481 647 390L600 137H596L273 650H126L120 622C176 620 194 615 207 594C221 571 225 557 214 504L161 257C141 166 129 112 121 85C108 42 83 30 29 28L23 0H260L266 28C193 33 173 42 176 89C178 122 186 172 202 255L256 527H259L583 -8H612L690 390C708 481 720 535 728 558C744 603 756 619 816 622L822 650Z"></path></g><g transform="matrix(.013,0,0,-0.013,14.542,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,25.805,0)"><path d="M285 378C315 398 338 416 353 432C373 451 384 474 384 503C384 579 325 635 236 635H235C182 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International Journal of Genomics

fig7

Figure 7

Figure 7: HMOX1 Attenuates the Sensitivity of Hepatocellular Carcinoma Cells to Sorafenib via Modulating the Expression of ABC Transporters 