Inhibition of lncRNA NFIA-AS1 Alleviates Abnormal Proliferation and Inflammation of Vascular Smooth Muscle Cells in Atherosclerosis by Regulating miR-125a-3p/AKT1 Axis

Figure 6

Inhibition of NFIA-AS1 alleviates the proliferation and inflammation of Ox-LDL-induced VSMCs by regulating miR-125a-3p/AKT1 axis. Ox-LDL-induced VSMCs were divided into four groups: si-NC + NC-inhibit + si-NC, si-NFIA-AS1 + NC-inhibit + si-NC, si-NFIA-AS1 + miR-125a-3p-inhibit + si-NC, and si-NFIA-AS1 + miR-125a-3p-inhibit + si-AKT1. (a) Cell viability was detected via CCK-8 assay. *, **, and ***. (b) Cells were stained with PI and the apoptosis rate was detected by flow cytometry. (c) The level of inflammatory cytokines was assessed by ELISA. ** and ***versus si-NC + NC-inhibit + si-NC group. ^# and ^##versus si-NFIA-AS1 + miR-125a-3p-inhibit + si-NC group. All results were obtained from three independent experiments.

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