An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene

Table 1

Functional domains predicted by Pfam.

Family name	Family description	Entry type	Start position	End position	E-value	Amino acid substitutions
Sema	Semaphorins	Domain	317	493		A320V, D340G, A364T
PSI	Plexin repeat	Domain	519	562	0.19
TIG	Ig-like fold	Domain	563	654
TIG	Ig-like fold	Domain	657	738
TIG	Ig-like fold	Domain	742	833		G757E
PK Tyr Ser-Thr	Receptor tyrosine kinase	Domain	1078	1337		H1094R, H1094Y, M1131T, S1141L, D1180N, V1188L, L1195V, D1228N, Y1230H, and T1261A