An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene

Table 2

Ligand binding sites predicted by RaptorX.

Domain	Pocket	Multiplicity	Ligand	Binding residues	Deleterious nsSNPs
1	1	63	ALQ	P51 Q53 N54 T67 I116 N117 M118 S135 L180 A182 K248 S487 G507
	2	15	UNX	H61 V81 H150 T151 A152
2	3	97	M97	I1084 V1092 A1108 K1110 E1127 M1131 L1140 L1157 P1158 Y1159 M1160 K1161 G1163 D1164 R1208 N1209 M1211 A1221 D1222 F1223	M1131T
3	4	77	BMA	S663 K665
	5	76	NAG	S663 T676 T678 G679 I706
	6	72	MAN	K665 L674 T676 S771
	7	17	GAL	Y666 G667 G672 T673 L674 D824
4	8	79	DA	D866 P867 E868 S889

M97: 1-[(3R,4R)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1ij]quinolinium; ALQ: 2-METHYL-PROPIONIC ACID; BMA: beta-D-mannopyranose; NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose; MAN: alpha-D-mannopyranose; GAL: beta-D-galactopyranose; DA: 2′-DEOXYADENOSINE-5′-MONOPHOSPHATE.