An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET Gene

Table 3

Docking analysis of native and mutant complexes.

Protein (receptor)	Ligand	Global binding energy
Native MET receptor	NK1	−4.00
	NK2	−8.41
Mutant A238S	NK1	−4.00
	NK2	−8.41
Mutant A320V	NK1	−0.60
	NK2	−8.41
Mutant P239R	NK1	−4.00
	NK2	−8.41
Mutant A364T	NK1	6.31
	NK2	−8.41
Mutant D340G	NK1	−4.00
	NK2	−8.41
Mutant T222M	NK1	−4.00
	NK2	−11.86