International Journal of Genomics

Noncoding RNAs in Health and Disease


Status
Published

1University of Catania, Catania, Italy

2Universitaria San Martino, Genoa, Italy


Noncoding RNAs in Health and Disease

Description

Over the past two decades, the structural and functional complexity of eukaryotic genomes has been confirmed. Most of the attention has specifically fallen on the RNA world. The advent of new molecular biology techniques (e.g., high-throughput sequencing of DNA and RNA), together with the outbreak of computational biology, has allowed identifying a plethora of transcripts that are not translated into proteins: these have been named noncoding RNAs (ncRNAs). Many in silico, in vitro, and in vivo studies have been focused on the characterization of expression profiles and molecular functions of these ncRNAs (i.e., microRNAs, piwi-interacting RNAs, long noncoding RNAs, and circRNAs), both in physiological and in pathological conditions. Accordingly, the pathogenetic involvement of many ncRNAs in several neoplastic and degenerative diseases has been demonstrated, but more knowledge needs to be gathered to pinpoint their precise mechanic and systemic role in controlling the genotype-phenotype relationship and their causal involvement in pathology. This special issue will be focused on new findings on these issues as on the different molecular strategies ncRNAs exploit to regulate gene expression; it will also include papers describing ncRNAs use as biomarkers for pathological conditions or response to a pharmacological treatment.

Potential topics include but are not limited to the following:

  • Involvement of noncoding RNAs in cancer
  • Involvement of noncoding RNAs in degenerative, neurodegenerative, and neuropsychiatric disorders
  • Epigenetics of noncoding RNAs
  • Cellular networks of noncoding RNAs
  • Evolution of noncoding RNAs

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9135073
  • - Editorial

Noncoding RNAs in Health and Disease

Davide Barbagallo | Gaetano Vittone | ... | Michele Purrello
  • Special Issue
  • - Volume 2017
  • - Article ID 6218353
  • - Review Article

Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers

Luka Bolha | Metka Ravnik-Glavač | Damjan Glavač
  • Special Issue
  • - Volume 2017
  • - Article ID 7639084
  • - Review Article

MicroRNA in Glioblastoma: An Overview

Barbara Banelli | Alessandra Forlani | ... | Massimo Romani
  • Special Issue
  • - Volume 2017
  • - Article ID 4723193
  • - Review Article

Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer

Marco Ragusa | Cristina Barbagallo | ... | Michele Purrello
  • Special Issue
  • - Volume 2017
  • - Article ID 5214806
  • - Research Article

The miRNA Pull Out Assay as a Method to Validate the miR-28-5p Targets Identified in Other Tumor Contexts in Prostate Cancer

Milena Rizzo | Gabriele Berti | ... | Giuseppe Rainaldi
  • Special Issue
  • - Volume 2017
  • - Article ID 2312318
  • - Research Article

Identifying Novel Glioma-Associated Noncoding RNAs by Their Expression Profiles

Alenka Matjašič | Mojca Tajnik | ... | Damjan Glavač
  • Special Issue
  • - Volume 2017
  • - Article ID 9769171
  • - Research Article

Tissue- and Cell Type-Specific Expression of the Long Noncoding RNA Klhl14-AS in Mouse

Sara Carmela Credendino | Nicole Lewin | ... | Gabriella De Vita
  • Special Issue
  • - Volume 2017
  • - Article ID 6496570
  • - Review Article

MicroRNAs as Biomarkers in Thyroid Carcinoma

Marilena Celano | Francesca Rosignolo | ... | Stefania Bulotta
  • Special Issue
  • - Volume 2017
  • - Article ID 5913195
  • - Review Article

Biological Function of MicroRNA193a-3p in Health and Disease

Ilaria Grossi | Alessandro Salvi | ... | Giuseppina De Petro
  • Special Issue
  • - Volume 2017
  • - Article ID 8737649
  • - Research Article

Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses

Antonella Izzo | Rosanna Manco | ... | Lucio Nitsch
International Journal of Genomics
 Journal metrics
Acceptance rate35%
Submission to final decision76 days
Acceptance to publication31 days
CiteScore3.400
Impact Factor2.414
 Submit