International Journal of Genomics

Genomics Approach of the Natural Product Pharmacology for High Impact Diseases


Status
Published

Lead Editor

1State University of New York at Buffalo, Buffalo, USA

2Shanghai University of TCM, Shanghai, China

3Beijing University of Chinese Medicine, Beijing, China

4Emory University, Atlanta, USA

5University of Tennessee, Knoxville, USA


Genomics Approach of the Natural Product Pharmacology for High Impact Diseases

Description

In recent years, natural product medicine has drawn great attention from people around the world and has been playing important roles in the prevention and treatment of high impact diseases (HID). Natural products are a great source of therapeutic agents and nearly a quarter of patent drugs are extracts or derivatives of natural products. For example, artemisinin is an extract from sweet wormwood. In 2015, Youyou Tu won the 2015 Nobel Prize for Medicine for her discovery of artemisinin in the treatment of malaria.

Investigations of the pharmacological mechanisms of these natural products or their extracts have been hampered by the fact that natural products are of complex composition. A single herbal plant may have dozens of active components that has diverse effects on various pathways in different organs and tissues of the patients.

Recent progress in high throughput technologies, including genomic sequencing, transcriptome, proteomics, and metabolomics techniques, has enabled the use of whole-genome approaches to obtain a comprehensive understanding of the pharmacological mechanisms of natural product medicine. High throughput technologies are especially useful for illustrating the multicomponents and multitargets mode of actions by natural products. This issue will be a collection of gems demonstrating how these omics approaches are shaping our current understanding of natural products at the genomic level.

Potential topics include but are not limited to the following:

  • Application of genomics approaches on natural products
  • Pharmacological study of natural products on HID using omics technologies
  • Toxicity evaluation of natural products by high throughput in vivo or in vitro studies
  • Omics based research (genomics, metagenomics, transcriptomics, proteomics, metabolomics, etc.) of ingredients or monomers from natural products in basic or clinical research
  • Studies using new methodological paradigms that challenge current genomics analysis of natural products

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 9468912
  • - Editorial

Genomics Approach of the Natural Product Pharmacology for High Impact Diseases

Yong Wang | Qin Feng | ... | Guoxun Chen
  • Special Issue
  • - Volume 2018
  • - Article ID 7697356
  • - Research Article

Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine

Jihye Kim | Minjae Yoo | ... | Aik Choon Tan
  • Special Issue
  • - Volume 2018
  • - Article ID 1361402
  • - Research Article

Urinary Metabolomic Study of Chlorogenic Acid in a Rat Model of Chronic Sleep Deprivation Using Gas Chromatography-Mass Spectrometry

Wei-ni Ma | Ming-mei Zhou | ... | Hong-yi Shen
  • Special Issue
  • - Volume 2018
  • - Article ID 9469670
  • - Research Article

Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia

Qiyan Wang | Hui Meng | ... | Yong Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 2790864
  • - Research Article

Lingguizhugan Decoction Protects against High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease by Alleviating Oxidative Stress and Activating Cholesterol Secretion

Lili Yang | Weili Lin | ... | Peiyong Zheng
  • Special Issue
  • - Volume 2017
  • - Article ID 7421761
  • - Research Article

Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice

Jing Han | Zhenglin Wang | ... | Yan Wu
  • Special Issue
  • - Volume 2017
  • - Article ID 4832125
  • - Research Article

HuoXueJieDu Formula Alleviates Diabetic Retinopathy in Rats by Inhibiting SOCS3-STAT3 and TIMP1-A2M Pathways

Hongliang Wang | Wei Xing | ... | Wei Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 5179271
  • - Research Article

Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment

Xiao-jun Gou | Fang Cen | ... | Ming-mei Zhou
  • Special Issue
  • - Volume 2017
  • - Article ID 2175871
  • - Research Article

miRNA Expression Profile and Effect of Wenxin Granule in Rats with Ligation-Induced Myocardial Infarction

Aiming Wu | Lixia Lou | ... | Mingjing Zhao
International Journal of Genomics
 Journal metrics
Acceptance rate35%
Submission to final decision76 days
Acceptance to publication31 days
CiteScore3.400
Impact Factor2.414
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