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International Journal of Hepatology
Volume 2011 (2011), Article ID 142085, 7 pages
http://dx.doi.org/10.4061/2011/142085
Review Article

Early Hepatocellular Carcinoma: Transplantation versus Resection: The Case for Liver Resection

Department of Surgery, Saint Agnes Hospital, 900 Caton Avenue, Mailbox #207, Baltimore, MD 21229, USA

Received 4 January 2011; Accepted 27 February 2011

Academic Editor: Pierce Chow

Copyright © 2011 Nishant Merchant et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. D. Yang and L. R. Roberts, “Hepatocellular carcinoma: a global view,” Nature Reviews Gastroenterology and Hepatology, vol. 7, pp. 448–458, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. H. B. El-Serag and A. C. Mason, “Rising incidence of hepatocellular carcinoma in the United States,” New England Journal of Medicine, vol. 340, no. 10, pp. 745–750, 1999. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. H. Nordenstedt, D. L. White, and H. B. El-Serag, “The changing pattern of epidemiology in hepatocellular carcinoma,” Digestive and Liver Disease, vol. 42, no. 3, pp. 206–214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. H. B. El-Serag and K. L. Rudolph, “Hepatocellular carcinoma: epidemiology and molecular carcinogenesis,” Gastroenterology, vol. 132, no. 7, pp. 2557–2576, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. H. Bismuth, L. Chiche, R. Adam, D. Castaing, T. Diamond, and A. Dennison, “Liver resection versus transplantation for hepatocellular carcinoma in cirrhotic patients,” Annals of Surgery, vol. 218, no. 2, pp. 145–151, 1993. View at Google Scholar · View at Scopus
  6. V. Mazzaferro, E. Regalia, R. Doci et al., “Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis,” New England Journal of Medicine, vol. 334, no. 11, pp. 693–699, 1996. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. J. N. Vauthey, E. Dixon, E. K. Abdalla et al., “Pretreatment assessment of hepatocellular carcinoma: expert consensus statement,” HPB, vol. 12, no. 5, pp. 289–299, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. R. Pichlmayr, A. Weimann, and B. Ringe, “Indications for liver transplantation in hepatobiliary malignancy,” Hepatology, vol. 20, no. 1, part 2, pp. 335–405, 1994. View at Google Scholar · View at Scopus
  9. R. Pichlmayr, “Is there a place for liver grafting for malignancy?” Transplantation Proceedings, vol. 20, no. 1, pp. 478–482, 1988. View at Google Scholar · View at Scopus
  10. S. Iwatsuki, R. D. Gordon, B. W. Shaw Jr., and T. E. Starzl, “Role of liver transplantation in cancer therapy,” Annals of Surgery, vol. 202, no. 4, pp. 401–407, 1985. View at Google Scholar · View at Scopus
  11. R. L. Jenkins, C. Wright Pinson, and M. D. Stone, “Experience with transplantation in the treatment of liver cancer,” Cancer Chemotherapy and Pharmacology, vol. 23, pp. S104–S109, 1989. View at Google Scholar · View at Scopus
  12. S. Iwatsuki, T. E. Starzl, S. Todo et al., “Experience in 1,000 liver transplants under cyclosporine-steroid therapy: a survival report,” Transplantation Proceedings, vol. 20, no. 1, supplement 1, pp. 498–504, 1988. View at Google Scholar · View at Scopus
  13. OPTN, “Organ Procurement and Transplantation Network,” December 2010, http://optn.transplant.hrsa.gov/.
  14. A. Vitale, P. Boccagni, A. Brolese et al., “Progression of hepatocellular carcinoma before liver transplantation: dropout or liver transplantation?” Transplantation Proceedings, vol. 41, no. 4, pp. 1264–1267, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. F. Y. Yao, N. M. Bass, N. L. Ascher, and J. P. Roberts, “Liver transplantation for hepatocellular carcinoma: lessons from the first year under the Model of End-Stage Liver Disease (MELD) organ allocation policy,” Liver Transplantation, vol. 10, no. 5, pp. 621–630, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. F. Y. Yao, N. M. Bass, B. Nikolai et al., “Liver transplantation for hepatocellular carcinoma: analysis of survival according to the intention-to-treat principle and Dropout from the waiting list,” Liver Transplantation, vol. 8, no. 10, pp. 873–883, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. J. Pelletier, S. Fu, V. Thyagarajan et al., “An intention-to-treat analysis of liver transplantation for hepatocellular carcinoma using organ procurement transplant network data,” Liver Transplantation, vol. 15, no. 8, pp. 859–868, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. M. E. Facciuto, C. Rochon, M. Pandey et al., “Surgical dilemma: liver resection or liver transplantation for hepatocellular carcinoma and cirrhosis. Intention-to-treat analysis in patients within and outwith Milan criteria,” HPB, vol. 11, no. 5, pp. 398–404, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. J. M. Llovet, J. Fuster, and J. Bruix, “Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation,” Hepatology, vol. 30, no. 6, pp. 1434–1440, 1999. View at Google Scholar · View at Scopus
  20. C. H. Cha, L. Ruo, Y. Fong et al., “Resection of hepatocellular carcinoma in patients otherwise eligible for transplantation,” Annals of Surgery, vol. 238, no. 3, pp. 315–323, 2003. View at Google Scholar · View at Scopus
  21. R. T. P. Poon, S. T. Fan, C. M. Lo, C. L. Liu, and J. Wong, “Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: Implications for a strategy of salvage transplantation,” Annals of Surgery, vol. 235, no. 3, pp. 373–382, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Del Gaudio, G. Ercolani, M. Ravaioli et al., “Liver transplantation for recurrent hepatocellular carcinoma on cirrhosis after liver resection: University of Bologna experience,” American Journal of Transplantation, vol. 8, no. 6, pp. 1177–1185, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. S. C. Cunningham, S. Tsai, H. P. Marques et al., “Management of early hepatocellular carcinoma in patients with well-compensated cirrhosis,” Annals of Surgical Oncology, vol. 16, no. 7, pp. 1820–1831, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. J. M. Llovet, J. Bruix, J. Fuster et al., “Liver transplantation for small hepatocellular carcinoma: the tumor- node-metastasis classification does not have prognostic power,” Hepatology, vol. 27, no. 6, pp. 1572–1577, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. J. Yamamoto, S. Iwatsuki, T. Kosuge et al., “Should hepatomas be treated with hepatic resection or transplantation?” Cancer, vol. 86, no. 7, pp. 1151–1158, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. P. E. Majno, F. P. Sarasin, G. Mentha, and A. Hadengue, “Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis,” Hepatology, vol. 31, no. 4, pp. 899–906, 2000. View at Google Scholar · View at Scopus
  27. H. Bismuth, P. E. Majno, and R. Adam, “Liver transplantation for hepatocellular carcinoma,” Seminars in Liver Disease, vol. 19, no. 3, pp. 311–321, 1999. View at Google Scholar · View at Scopus
  28. R. Adam, D. Azoulay, D. Castaing et al., “Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: a reasonable strategy?” Annals of Surgery, vol. 238, no. 4, pp. 508–519, 2003. View at Google Scholar · View at Scopus
  29. J. Belghiti, A. Cortes, E. K. Abdalla et al., “Resection prior to liver transplantation for hepatocellular carcinoma,” Annals of Surgery, vol. 238, no. 6, pp. 885–893, 2003. View at Google Scholar · View at Scopus
  30. D. Cherqui, A. Laurent, N. Mocellin et al., “Liver resection for transplantable hepatocellular carcinoma: long-term survival and role of secondary liver transplantation,” Annals of Surgery, vol. 250, no. 5, pp. 738–745, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. M. Sala, J. Fuster, J. M. Llovet et al., “High pathological risk of recurrence after surgical resection for hepatocellular carcinoma: an indication for salvage liver transplantation,” Liver Transplantation, vol. 10, no. 10, pp. 1294–1300, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. O. Scatton, S. Zalinski, B. Terris et al., “Hepatocellular carcinoma developed on compensated cirrhosis: resection as a selection tool for liver transplantation,” Liver Transplantation, vol. 14, no. 6, pp. 779–788, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. I. Dagher, G. Belli, C. Fantini et al., “Laparoscopic hepatectomy for hepatocellular Carcinomac: a European experience,” Journal of the American College of Surgeons, vol. 211, no. 1, pp. 16–23, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. R. Bahirwani and K. R. Reddy, “Outcomes after liver transplantation: chronic kidney disease,” Liver Transplantation, vol. 15, pp. S70–S74, 2009. View at Google Scholar · View at Scopus
  35. A. Jain, J. Reyes, R. Kashyap et al., “What have we learned about primary liver transplantation under tacrolimus immunosuppression?—Long-term follow-up of the first 1000 patients,” Annals of Surgery, vol. 230, no. 3, pp. 441–449, 1999. View at Publisher · View at Google Scholar
  36. E. J. Gane, N. V. Naoumov, K. P. Qian et al., “A longitudinal analysis of hepatitis C virus replication following liver transplantation,” Gastroenterology, vol. 110, no. 1, pp. 167–177, 1996. View at Publisher · View at Google Scholar · View at Scopus
  37. J. I. Herrero, “De novo malignancies following liver transplantation: impact and recommendations,” Liver Transplantation, vol. 15, supplement 2, pp. S90–S94, 2009. View at Google Scholar · View at Scopus
  38. K. Kataoka, S. Seo, Y. Sugawara et al., “Post-transplant lymphoproliferative disorder after adult-to-adult living donor liver transplant: case series and review of literature,” Leukemia and Lymphoma, vol. 51, no. 8, pp. 1494–1501, 2010. View at Publisher · View at Google Scholar · View at PubMed
  39. D. Marino, P. Burra, P. Boccagni et al., “Post-transplant lymphoproliferative disorders in liver transplanted patients: a single-centre experience,” Anticancer Research, vol. 30, no. 6, pp. 2383–2391, 2010. View at Google Scholar
  40. B. Geramizadeh, S.-A. Malek-Hosseini, A. Bahador et al., “Post-transplantation lymphoproliferative disorder after liver transplantation: report of 5 cases among more than 550 liver transplants in Iran,” Archives of Iranian Medicine, vol. 13, no. 5, pp. 417–419, 2010. View at Google Scholar
  41. R. Potru, J. Ahn, H. Fung, and S. M. Cohen, “A case of myelodysplastic syndrome in a liver transplant patient,” Transplantation Proceedings, vol. 41, no. 9, pp. 3947–3948, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. C. Vanlemmens, V. Di Martino, C. Milan et al., “Immediate listing for liver transplantation versus standard care for Child-Pugh stage B alcoholic cirrhosis. A Randomized Trial,” Annals of Internal Medicine, vol. 150, no. 3, pp. 153–161, 2009. View at Google Scholar · View at Scopus
  43. C. L. Bryce, D. C. Angus, R. M. Arnold et al., “Sociodemographic differences in early access to liver transplantation services,” American Journal of Transplantation, vol. 9, no. 9, pp. 2092–2101, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  44. R. T. Schweizer, M. Rovelli, D. Palmeri, E. Vossler, D. Hull, and S. Bartus, “Noncompliance in organ transplant recipients,” Transplantation, vol. 49, no. 2, pp. 374–377, 1990. View at Google Scholar · View at Scopus
  45. A. Artinyan, B. Mailey, N. Sanchez-Luege et al., “Race, ethnicity, and socioeconomic status influence the survival of patients with hepatocellular carcinoma in the United States,” Cancer, vol. 116, no. 5, pp. 1367–1377, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. S. Iwatsuki, T. E. Starzl, D. G. Sheahan et al., “Hepatic resection versus transplantation for hepatocellular carcinoma,” Annals of Surgery, vol. 214, no. 3, pp. 221–229, 1991. View at Google Scholar · View at Scopus
  47. B. Ringe, R. Pichlmayr, C. Wittekind, and G. Tusch, “Surgical treatment of hepatocellular carcinoma: experience with liver resection and transplantation in 198 patients,” World Journal of Surgery, vol. 15, no. 2, pp. 270–285, 1991. View at Google Scholar · View at Scopus
  48. V. Vargas, L. Castells, J. Balsells et al., “Hepatic resection or orthotopic liver transplant in cirrhotic patients with small hepatocellular carcinoma,” Transplantation Proceedings, vol. 27, no. 1, pp. 1243–1244, 1995. View at Google Scholar · View at Scopus
  49. K. C. Tan, M. Rela, S. D. Ryder et al., “Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis,” British Journal of Surgery, vol. 82, no. 2, pp. 253–256, 1995. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Michel, B. Suc, F. Montpeyroux et al., “Liver resection or transplantation for hepatocellular carcinoma? Retrospective analysis of 215 patients with cirrhosis,” Journal of Hepatology, vol. 26, no. 6, pp. 1274–1280, 1997. View at Publisher · View at Google Scholar · View at Scopus
  51. B. Philosophe, P. D. Greig, A. W. Hemming et al., “Surgical management of hepatocellular carcinoma: resection or transplantation?” Journal of Gastrointestinal Surgery, vol. 2, no. 1, pp. 21–27, 1998. View at Google Scholar · View at Scopus
  52. G. Colella, L. de Carlis, G. F. Rondinara et al., “Is hepatocellular carcinoma in cirrhosis an actual indication for liver transplantation?” Transplantation Proceedings, vol. 29, no. 1-2, pp. 492–494, 1997. View at Publisher · View at Google Scholar · View at Scopus
  53. A. Mazziotti, G. L. Grazi, and A. Cavallari, “Surgical treatment of hepatocellular carcinoma on cirrhosis: a Western experience,” Hepato-Gastroenterology, vol. 45, supplement 3, pp. 1281–1287, 1998. View at Google Scholar
  54. G. Otto, U. Heuschen, W. J. Hofmann, G. Krumm, U. Hinz, and C. Herfarth, “Survival and recurrence after liver transplantation versus liver resection for hepatocellular carcinoma: a retrospective analysis,” Annals of Surgery, vol. 227, no. 3, pp. 424–432, 1998. View at Publisher · View at Google Scholar · View at Scopus
  55. A. Weimann, H. J. Schlitt, K. J. Oldhafer, S. Hoberg, G. Tusch, and R. Raab, “Is liver transplantation superior to resection in early stage hepatocellular carcinoma?” Transplantation Proceedings, vol. 31, no. 1-2, pp. 500–501, 1999. View at Publisher · View at Google Scholar · View at Scopus
  56. J. Figueras, E. Jaurrieta, C. Valls et al., “Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: on indicated treatment strategy,” Journal of the American College of Surgeons, vol. 190, no. 5, pp. 580–587, 2000. View at Google Scholar
  57. L. de Carlis, A. Giacomoni, V. Pirotta et al., “Treatment of HCC: the role of liver resection in the era of transplantation,” Transplantation Proceedings, vol. 33, no. 1-2, pp. 1453–1456, 2001. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Shabahang, D. Franceschi, N. Yamashiki et al., “Comparison of hepatic resection and hepatic transplantation in the treatment of hepatocellular carcinoma among cirrhotic patients,” Annals of Surgical Oncology, vol. 9, no. 9, pp. 881–886, 2002. View at Google Scholar · View at Scopus
  59. J. M. Bigourdan, D. Jaeck, N. Meyer et al., “Small hepatocellular carcinoma in child A cirrhotic patients: hepatic resection versus transplantation,” Liver Transplantation, vol. 9, no. 5, pp. 513–520, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. J. P. E. N. Pierie, A. Muzikansky, K. K. Tanabe, and M. J. Ott, “The outcome of surgical resection versus assignment to the liver transplant waiting list for hepatocellular carcinoma,” Annals of Surgical Oncology, vol. 12, no. 7, pp. 552–560, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  61. C. Margarit, A. Escartín, L. Castells, V. Vargas, E. Allende, and I. Bilbao, “Resection for hepatocellular carcinoma is a good option in Child-Turcotte-Pugh class a patients with cirrhosis who are eligible for liver transplantation,” Liver Transplantation, vol. 11, no. 10, pp. 1242–1251, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. R. T. P. Poon, S. T. Fan, C. M. Lo, C. L. Liu, and J. Wong, “Difference in tumor invasiveness in cirrhotic patients with hepatocellular carcinoma fulfilling the Milan criteria treated by resection and transplantation: impact on long-term survival,” Annals of Surgery, vol. 245, no. 1, pp. 51–58, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  63. U. Cillo, A. Vitale, A. Brolese et al., “Partial hepatectomy as first-line treatment for patients with hepatocellular carcinoma,” Journal of Surgical Oncology, vol. 95, no. 3, pp. 213–220, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  64. E. C. Bellavance, K. M. Lumpkins, G. Mentha et al., “Surgical management of early-stage hepatocellular carcinoma: resection or transplantation?” Journal of Gastrointestinal Surgery, vol. 12, no. 10, pp. 1699–1708, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  65. G. C. Sotiropoulos, N. Drühe, G. Sgourakis et al., “Liver transplantation, liver resection, and transarterial chemoembolization for hepatocellular carcinoma in cirrhosis: which is the best oncological approach?” Digestive Diseases and Sciences, vol. 54, no. 10, pp. 2264–2273, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  66. J. Zhou, Z. Wang, S. J. Qiu et al., “Surgical treatment for early hepatocellular carcinoma: comparison of resection and liver transplantation,” Journal of Cancer Research and Clinical Oncology, vol. 136, no. 9, pp. 1453–1460, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus