Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1
TNF-α, IL-6, and Cox2 mRNA expression levels and NFκB/Stat3 activation after LN treatment. (a) Quantitative RT-PCR revealed that TNF-α, IL-6, and Cox2 mRNA expression levels peaked at 6 h after LN treatment in Donryu, DRH, and DRH.F344-Drh1 livers. (b) EMSA for NFκB (upper panel) and Stat3 (lower panel). Both NFκB and Stat3 were most strongly activated at 6 h after LN treatment in Donryu, DRH, and DRH.F344-Drh1 livers. NS: nonspecific bands.
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