Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1
Nuclear size of hepatocytes. (a) DRH.F344-Drh1 and DRH hepatocytes exhibited mainly single- (S) or double-small-sized nuclei (2S), while Donryu and F344 hepatocytes exhibited mainly single- (M) or double-medium-sized nuclei (2M). (b) Size distribution of hepatocyte nuclei. In DRH.F344-Drh1 and DRH rats, about 60% hepatocytes contain single- or double-small-sized nuclei, while other hepatocytes contain single-medium-sized nuclei. On the other hand, in Donryu and F344 rats, the majority of hepatocytes contain single- or double-medium-sized nuclei.
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