Unique Properties of Hepatocarcinogenesis-Resistant DRH Rat Hepatocytes Linked or Not Linked to the Drh1 Locus on Rat Chromosome 1

Table 1

Comparison of hepatocytes from Donryu, DRH, DRH.F344-Drh1, and F344 rats.

	Donryu	DRH	DRH.F344-Drh1	F344
Proliferation by LN	High	Low*	High*	High
P38 dephosphorylation	High	Low*	High*	High
Susceptibility to DEN and CCl4	High	Low*	High*	High^†
Proliferation by GF	High	Low**	Low**	High
Nuclear size	Large	Small**	Small**	Large

*Phenotype different between DRH and DRH.F344-Drh1. **Phenotype similar between DRH and DRH.F344-Drh1. ^†High to DEN as Donryu, but lower to CCl₄ than Donryu.