Review Article

Multimodal Liver-Directed Management of Neuroendocrine Hepatic Metastases

Table 6

Summary of outcomes for liver transplantation for neuroendocrine metastases. OS: overall survival.

Author, publication yearNo. of liver transplant (LT) patientsSurvival dataPredictors of survival

Gedaly, 2011 [76]150 [13 receiving another organ at time of LT]49% 5-year survival [excluding multiple organ transplants]Regardless of age, improved survival (>60% at 5 years) for patients waiting more than 2 months for transplant ( )
Mathe, 2011 [77]8944% 5-year survivalWorse survival with recipient age >55 ( ) and simultaneous LT-pancreas resection ( )
Rosenau, 2002 [78]1980% 5-year survival
50% 10-year survival
Ki-67 <5% and normal E-cadherin expression had 100% 7-year survival (versus 0% when Ki-67% >5% or aberrant E-cadherin expression, )
Le Treut, 2008 [79]85 [34 with concurrent extrahepatic resection]Median OS: 56 monthsExenteration ( ), a duodenopancreatic primary ( ), and hepatomegaly ( ), all predicted for poorer survival