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International Journal of Hepatology
Volume 2011, Article ID 785315, 5 pages
Review Article

Radioembolization in the Treatment of Neuroendocrine Tumor Metastases to the Liver

Department of Radiology, University of Louisville School of Medicine, Louisville, KY 40202, USA

Received 11 July 2011; Accepted 1 November 2011

Academic Editor: Dan Granberg

Copyright © 2011 Martin Vyleta and Douglas Coldwell. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Surgical excision remains the preferred treatment for resectable hepatic metastases of neuroendocrine tumors. In cases of more disseminated hepatic disease, transarterial radioembolization with Yttrium-90- (90Y-) labeled microspheres has been demonstrated as a viable option for symptom and locoregional tumor control. On an outpatient basis, radioembolization can be utilized from early line to salvage phases, in various combinations with systemic therapies. Review of available data shows encouraging safety and efficacy profiles for the intraarterial application of 90Y for the treatment of mNETs of the liver. Symptom control and decrease in somatostatin analog use can be achieved, as well as prolonged survival.