Treatment of Hepatitis B in Decompensated Liver Cirrhosis

Table 3

Antiviral Agents with Activity against Wild Type and Lamivudine resistant HBV.

Agent	Daily dose	Side effects	Comments
Adefovir	10 mg	Dose-dependant nephrotoxicity	Drug resistance after 12 months
Entecavir	1 mg	No major side effects to date	Drug resistance eventually in lamivudine-resistant mutants
Tenofovir	300 mg	Neuropathy, nausea, CPK elevations, Fanconi syndrome	No drug resistance up to 4 years