Fractalkine and Other Chemokines in Primary Biliary Cirrhosis

Figure 1

Chemokines produced by biliary epithelial cells under basal conditions or after stimulation with TLR3 ligand (poly I : C) for 48 hours. Cell-free culture supernatants were analyzed by a protein array kit to evaluate 174 different proteins simultaneously. Unstimulated cells produced detectable amounts of GRO-α/CXCL1, ENA-78/CXCL5, GCP-2/CXCL6, and IL-8/CXCL8, while poly I : C stimulation led to enhanced MIP-1α/CCL3, MIP-1β/CCL4, RANTES/CCL5, and IP-10/CXCL10.