Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients

Table 2

Pathogenic fungi and the antifungal agents in vitro activity**.

Microorganism	Antifungal agents
	Fluconazole	Voriconazole	Posaconazole	Echinocandin	Polyenes
Candida albicans	1st line	1st line	1st line	1st line	1st line
Candida glabrata	Unknown	3rd line	3rd line	1st line	2nd line
Candida tropicalis	1st line	1st line	1st line	1st line	1st line
Candida parapsilosis	1st line	1st line	1st line	2nd line	1st line
Candida krusei	No activity	2nd line	2nd line	1st line	2nd line
Candida guilliermondii	1st line	1st line	1st line	2nd line	2nd line
Candida lusitaniae	3rd line	2nd line	2nd line	2nd line	2nd line
Cryptococcus neoformans	1st line	1st line	1st line	No activity	1st line
Aspergillus fumigatus	No activity	1st line	1st line	2nd line	2nd line
Aserpgillus flavus	No activity	1st line	1st line	2nd line	2nd line
Aspergillus terreus	No activity	1st line	1st line	2nd line	No activity
Fusarium sp.	No activity	2nd line	2nd line	No activity	2nd line
Scedosporium apiospermum	No activity	1st line	1st line	Unknown	Unknown
Scedosporium prolificans	No activity	Unknown	Unknown	No activity	Unknown
Trichosporon spp.	Unknown	2nd line	2nd line	No activity	3rd line
Zygomycetes (e.g., Absidia, Mucor, and Rhizopus)	No activity	No activity	1st line	No activity	1st line
Dematiaceous molds; (e.g., Alternaria,  Bipolaris,  Curvularia,  and Exophiala)	Unknown	1st line	1st line	3rd line	3rd line
Dimorphic Fungi
Blastomyces  dermatitidis	3rd line	2nd line	2nd line	No activity	1st line
Coccidioides  immitis	1st line	2nd line	2nd line	No activity	1st line
Histoplasma  capsulatum	3rd line	2nd line	2nd line	No activity	1st line
Sporothrix  schenckii	3rd line	2nd line	2nd line	No activity	1st line

**Echinocandins, voriconazole, posaconazole, and polyenes have poor urine penetration.