International Journal of Hepatology / 2012 / Article / Tab 5

Review Article

Fungal Infections: Their Diagnosis and Treatment in Transplant Recipients

Table 5

Pharmacokinetic parameters of the major echinocandins in clinical use*.

Agent 𝐢 m a x 𝑑 1 / 2 𝑉 𝑑 AUC 𝐢 𝑑 FeUFeS

Caspofungin7.64100.488–1150.151.40%35%
Micafungin4.95140.231110.190.70%40%
Anidulafungin2.07–3.5250.544–530.26<1%30%, <10% unchanged

*Dose 50 mg single dose, 𝐢 m a x : maximum concentration, 𝑑 1 / 2 : elimination half-life, 𝑉 𝑑 : volume of distribution, AUC: area under the plasma concentration and time curve, 𝐢 𝑑 : total clearance, FeU: fraction excreted in urine, FeS: fraction excreted in stool.

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