Regulation of Signal Transduction by Glutathione Transferases
Figure 1
The prostaglandin biosynthetic pathway (adapted from [1]) 15-deoxyΔ12-14-PGJ2 is a metabolite derived from arachidonic acid. Several GSTs are implicated in the regulation of its formation: GSTS1 metabolized PGH2 in PGD2; GSTA1, GSTM1, and GSTP1 conjugated GSH to PGJ2 and 15-deoxyΔ12-14-PGJ2. This conjugation led to the regulation of various transcription factors (PPARγ, NF-κB, and Nrf2).
