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International Journal of Hepatology
Volume 2012, Article ID 140147, 11 pages
http://dx.doi.org/10.1155/2012/140147
Review Article

The Nude Mouse as Model for Liver Deficiency Study and Treatment and Xenotransplantation

1Faculté de Médecine et de Pharmacie, EA 3921, IFR 133, 25030 Besançon, France
2Unit of Pediatric Surgery, Geneva University Hospital, 1211 Geneva, Switzerland
3KaLy-Cell, 20A rue du Général Leclerc, 67115 Plobsheim, France

Received 25 May 2012; Revised 13 August 2012; Accepted 7 September 2012

Academic Editor: Shay Soker

Copyright © 2012 Isabelle Vidal and Lysiane Richert. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acute toxic liver deficiency, chronic cirrhosis, and transgenic liver injury. The second part tackles the outcome of rat hepatocyte as well as human cell transplantation, both mature hepatocyte and hepatic progenitor, into Nude mouse submitted to liver injury. Results are discussed and compared to other available immunodeficient mouse models. The issue of humanized liver creation is also addressed. Altogether, these results show that Nude mouse appears to be a suitable small animal model to expand our insight into liver cell engraftment and regeneration.