Review Article

Clinical Manifestations of Portal Hypertension

Table 6

Revised diagnostic criteria of Hepatorenal syndrome.

(i) Chronic or acute liver disease with advanced liver failure and portal hypertension
(ii) Plasma creatinine concentration > 1.5 mg/dL (133 micromol/L)
(iii) The absence of other apparent cause: shock, ongoing bacterial infection, volume depletion, current or recent use of nephrotoxic drugs
(iv) Lack of improvement in renal function after volume expansion with intravenous albumin (1 g/kg of body weight per day up to 100 g/day) for at least two days and withdrawal of diuretics
(v) Absence of parenchymal kidney disease as indicated by proteinuria >500 mg/day, microhematuria (>50 red blood cells per high power field) or ultrasonographic evidence of obstructive uropathy or renal parenchymal disease