Recovery of the Cell Cycle Inhibition in -Induced Cirrhosis by the Adenosine Derivative IFC-305
Figure 1
Effect of IFC305 treatment on the liver PCNA protein expression in CCl4-induced cirrhosis in rats. (a) Protein expression of PCNA and the house keeping gen β-actin from liver nuclear extracts was determined by western blot analysis. A representative western blot image is shown. The bar graph represents the densitometry analysis expressed as arbitrary units of the mean ± SEM from 3 rats/group; values were normalized to β-actin immunodetection. (b) Immunohistochemical analysis of PCNA expression. Hepatocyte (arrowhead) and nonparenchymal cell (arrow) are marked. The number of PCNA positive hepatocytes was quantified as described in Section 2. *Statistical difference () when compared to C group. #Statistical difference () when compared to their respective experimental group SS5 or SS10.
