Milan Criteria and UCSF Criteria: A Preliminary Comparative Study of Liver Transplantation Outcomes in the United States

Table 3

Univariate and multivariate analysis.

Factors	HR (95% CI)	P	HR (95% CI)	P
Age	1.02 (1.01–1.03)	0.005	1.02 (1.01–1.03)	0.002
Gender		0.03		0.11
Female	1.0	—	1.0	—
Male	0.80 (0.65–0.98)	0.03	1.20 (0.96–1.49)	0.11
Diabetes mellitus		0.29
No*	1.0	—	N/A	N/A
Yes	1.11 (0.91–1.36)	0.29
BMI	1.00 (0.98–1.02)	0.72	N/A	N/A
Number of tumors		0.78
1	1.0	—
2	0.95 (0.77–1.17)	0.63	N/A	N/A
3	0.91 (0.67–1.24)	0.55
Total Tumor Diameter	1.08 (1.01–1.16)	0.02	1.09 (1.01–1.18)	0.03
Liver directed therapy		0.04		0.06
No	1.0	—	1.0	—
Yes	0.82 (0.67–0.99)	0.04	1.22 (0.99–1.50)	0.06
Hepatitis B virus		0.47
Negative	1.0	—	N/A	N/A
Positive	0.93 (0.77–1.13)	0.47
Hepatitis C virus		0.02		0.004
Negative	1.0	—	1.0	—
Positive	1.26 (1.03–1.54)	0.02	1.34 (1.10–1.64)	0.004
Transplant criteria		0.22		0.32
Milan	1.0	—	1.0	—
UCSF	1.34 (0.84–2.15)	0.22	1.31 (0.77–2.21)	0.32

*Yes: type I or II; or type unknown.
HR: hazard ratio; CI: confidence interval; BMI: body mass index.