Pathological Features of New Animal Models for Primary Biliary Cirrhosis

Table 3

Novel PBC animal models reported since 2006.

---

Spontaneous models

(1) NOD.c3c4 mice [23–25]

(2) Dominant negative TGF-β receptor II mice [26–31]

(3) IL-2 receptor α ^−/− mice [32, 33]

(4) Scurfy mice [34]

(5) Ae2_a,b ^−/− mice [35]

---

Xenobiotic-immunized induced model

(1) 6-Bromohexanoate-immunized guinea pigs [36]

(2) 2-Octynoic acid-immunized mice [37–40]

---