International Journal of Hepatology / 2012 / Article / Tab 4

Review Article

Pathological Features of New Animal Models for Primary Biliary Cirrhosis

Table 4

Comparison of novel PBC animal models.

Spontaneous models  Xenobiotic-immunized   induced model
NOD.c3c4 micednTGF-βRII miceIL-2 Rα −/− mice Scurfy mice mice6-BH-immunized guinea pigs2-OA-immunized mice

Advantages
AMA50–60%100%100%100%40–80%100%100%
Dominant AMA target proteinPDC-E2PDC-E2PDC-E2PDC-E2PDC-E2PDC-E2PDC-E2
Biliary damage++++−+++−+++−+++++−++
Granuloma++− or +?++++
Pro-inflammatory cytokines+++++++

DisadvantagesBiliary dilatationmoderate colitisSevere colitis
Severe hemolytic anemia
Short lifespanLate onsetLate onsetperitonitis

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