Pathological Features of New Animal Models for Primary Biliary Cirrhosis

Table 4

Comparison of novel PBC animal models.

	Spontaneous models					Xenobiotic-immunized   induced model
	NOD.c3c4 mice	dnTGF-βRII mice	IL-2 Rα ^−/− mice	Scurfy mice	𝐴𝑒2𝑎,𝑏−/− mice	6-BH-immunized guinea pigs	2-OA-immunized mice
Advantages
AMA	50–60%	100%	100%	100%	40–80%	100%	100%
Dominant AMA target protein	PDC-E2	PDC-E2	PDC-E2	PDC-E2	PDC-E2	PDC-E2	PDC-E2
Biliary damage	+	++	+−++	+−++	+−+++	+	+−++
Granuloma	+	+	− or +	−	?	++	++
Pro-inflammatory cytokines	+	+	+	+	+	+	+
Disadvantages	Biliary dilatation	moderate colitis	Severe colitis; Severe hemolytic anemia	Short lifespan	Late onset	Late onset	peritonitis