Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse
Figure 2
(a) Effect of ethanol dose on elimination rate (β) and normalized AUC (AUC/dose) of blood ethanol. (b) Correlation of normalized AUC with β in mice for various doses of ethanol. β (○) and normalized AUC (□) were calculated from the regression line fitted to the blood ethanol concentrations at each dose in Figure 1.
