International Journal of Hepatology / 2012 / Article / Fig 2

Research Article

Dose-Dependent Change in Elimination Kinetics of Ethanol due to Shift of Dominant Metabolizing Enzyme from ADH 1 (Class I) to ADH 3 (Class III) in Mouse

Figure 2

(a) Effect of ethanol dose on elimination rate (β) and normalized AUC (AUC/dose) of blood ethanol. (b) Correlation of normalized AUC with β in mice for various doses of ethanol. β (○) and normalized AUC (□) were calculated from the regression line fitted to the blood ethanol concentrations at each dose in Figure 1.

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