A Crucial Role of Bone Morphogenetic Protein Signaling in the Wound Healing Response in Acute Liver Injury Induced by Carbon Tetrachloride
Figure 3
Liver injury in BMPR1A-KO mice. (a) Time course for the experiment. mice were infected with mock, Ad-Cre or Ad-LacZ for 14 days, followed by intraperitoneal administration of CCl4 for the indicated time. (b) Hematoxylin and eosin staining of tissue sections from the injured liver in mice. The hepatotoxicity of CCl4 causes necrotic damage to the centrilobular hepatocytes at 24 h. The recovery from the liver injury in BMPR1A-KO mice is retarded at 72 h after CCl4 injection compared with control mice. Scale bars: 50 μm. (c) AST activities in serum samples from CCl4-treated mice. All data are shown as the means ± SE from three independent experiments.
