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International Journal of Hepatology
Volume 2012, Article ID 487480, 6 pages
http://dx.doi.org/10.1155/2012/487480
Review Article

Acute Liver Failure Caused by Amanita phalloides Poisoning

1U.O. Semeiotica Medica, Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Via Albertoni 15, 40138 Bologna, Italy
2S.S.D. Liver Transplant, Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Via Albertoni 15, 40138 Bologna, Italy

Received 4 May 2012; Accepted 11 May 2012

Academic Editor: Bruno Nardo

Copyright © 2012 Luca Santi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Karlson-Stiber and H. Persson, “Cytotoxic fungi—an overview,” Toxicon, vol. 42, no. 4, pp. 339–349, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Enjalbert, S. Rapior, J. Nouguier-Soulé, S. Guillon, N. Amouroux, and C. Cabot, “Treatment of amatoxin poisoning: 20-Year retrospective analysis,” Journal of Toxicology, vol. 40, no. 6, pp. 715–757, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Bryngil, “Amanita phalloides,” Clinical Toxicology Review, vol. 21, pp. 191–198, 1999. View at Google Scholar
  4. C. N. Broussard, A. Aggarwal, S. R. Lacey et al., “Mushroom poisoning—from diarrhea to liver transplantation,” American Journal of Gastroenterology, vol. 96, no. 11, pp. 3195–3198, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Vetter, “Toxins of Amanita phalloides,” Toxicon, vol. 36, no. 1, pp. 13–24, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. C. Köppel, “Clinical symptomatology and management of mushroom poisoning,” Toxicon, vol. 31, no. 12, pp. 1513–1540, 1993. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Dart, “Mushrooms,” in Medical Toxicology, pp. 1719–1735, Williams & Wilkins, Philadelphia, Pa, USA, 2004. View at Google Scholar
  8. A. Himmelmann, G. Mang, and S. Schnorf-Huber, “Lethal ingestion of stored Amanita phalloides mushrooms,” Swiss Medical Weekly, vol. 131, no. 41-42, pp. 616–617, 2001. View at Google Scholar · View at Scopus
  9. P. A. Horgen, A. C. Vaisius, and J. F. Ammirati, “The insensitivity of mushroom nuclear RNA polymerase activity to inhibition by amatoxins,” Archives of Microbiology, vol. 118, no. 3, pp. 317–319, 1978. View at Google Scholar · View at Scopus
  10. K. J. Berger and D. A. Guss, “Mycotoxins revisited: part I,” Journal of Emergency Medicine, vol. 28, no. 1, pp. 53–62, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Busi, L. Fiume, and D. Costantino, “Amanita toxins in gastroduodenal fluid of patients poisoned by the mushroom, Amanita phalloides,” New England Journal of Medicine, vol. 300, no. 14, p. 800, 1979. View at Google Scholar · View at Scopus
  12. H. Faulstich, “New aspects of amanita poisoning,” Klinische Wochenschrift, vol. 57, no. 21, pp. 1143–1152, 1979. View at Google Scholar · View at Scopus
  13. J. Piqueras, “Hepatotoxic mushroom poisoning: diagnosis and treatment,” Mycopathologia, vol. 105, no. 2, pp. 99–110, 1989. View at Google Scholar · View at Scopus
  14. S. Vesconi, M. Langer, and G. Iapichino, “Therapy of cytotoxic mushroom intoxication,” Critical Care Medicine, vol. 13, no. 5, pp. 402–406, 1985. View at Google Scholar · View at Scopus
  15. A. Jaeger, F. Jehl, F. Flesch, P. Sauder, and J. Kopferschmitt, “Kinetics of amatoxins in human poisoning: therapeutic implications,” Journal of Toxicology, vol. 31, no. 1, pp. 63–80, 1993. View at Google Scholar · View at Scopus
  16. L. Fiume, S. Sperti, L. Montanaro, C. Busi, and D. Costantino, “Amanitins do not bind to serum albumin,” The Lancet, vol. 1, no. 8021, p. 1111, 1977. View at Google Scholar · View at Scopus
  17. H. Faulstich, A. Talas, and H. H. Wellhoner, “Toxicokinetics of labeled amatoxins in the dog,” Archives of Toxicology, vol. 56, no. 3, pp. 190–194, 1984. View at Google Scholar · View at Scopus
  18. R. B. Gibbons, “Mushroom poisoning,” Comprehensive Therapy, vol. 8, no. 12, pp. 33–39, 1982. View at Google Scholar · View at Scopus
  19. A. Manoguerra, “Amanita phalloides—type mushroom poisoning,” Bulletin of San Diego Regional Poison Control Center, vol. 6, p. 1, 1982. View at Google Scholar
  20. M. Derenzini, C. M. Betts, C. Busi, and L. Fiume, “Ultrastructural changes in β-cells of pancreatic islets in α-amanitin-poisoned mice,” Virchows Archiv B, vol. 28, no. 1, pp. 13–20, 1978. View at Google Scholar · View at Scopus
  21. M. Leist, F. Gantner, H. Naumann et al., “Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins,” Gastroenterology, vol. 112, no. 3, pp. 923–934, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Paaso and D. C. Harrison, “A new look at an old problem: mushroom poisoning. Clinical presentations and new therapeutic approaches,” American Journal of Medicine, vol. 58, no. 4, pp. 505–509, 1975. View at Google Scholar · View at Scopus
  23. P. Sanz, R. Reig, L. Borras, J. Martinez, R. Manez, and J. Corbella, “Disseminated intravascular coagulation and mesenteric venous thrombosis in fatal amanita poisoning,” Human Toxicology, vol. 7, no. 2, pp. 199–201, 1988. View at Google Scholar · View at Scopus
  24. A. Mas, “Mushrooms, amatoxins and the liver,” Journal of Hepatology, vol. 42, no. 2, pp. 166–169, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Butera, C. Locatelli, T. Coccini, and L. Manzo, “Diagnostic accuracy of urinary amanitin in suspected mushroom poisoning: a pilot study,” Journal of Toxicology, vol. 42, no. 6, pp. 901–912, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. X. Wittebole and P. Hantson, “Use of the molecular adsorbent recirculating system (MARS) for the management of acute poisoning with or without liver failure,” Clinical Toxicology, vol. 49, no. 9, pp. 782–793, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. R. Mitzner, J. Stange, S. Klammt, P. Peszynski, R. Schmidt, and G. Nöldge-Schomburg, “Extracorporeal detoxification using the molecular adsorbent recirculating system for critically ill patients with liver failure,” Journal of the American Society of Nephrology, vol. 12, no. 17, pp. S75–S82, 2001. View at Google Scholar · View at Scopus
  28. P. Faybik, H. Hetz, A. Baker et al., “Extracorporeal albumin dialysis in patients with Amanita phalloides poisoning,” Liver International, vol. 23, no. 3, pp. 28–33, 2003. View at Google Scholar · View at Scopus
  29. L. Sorodoc, C. Lionte, V. Sorodoc, O. Petris, and I. Jaba, “Is MARS system enough for A. phalloides-induced liver failure treatment?” Human and Experimental Toxicology, vol. 29, no. 10, pp. 823–832, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Hruby, G. Csomos, M. Fuhrmann, and H. Thaler, “Chemotherapy of Amanita phalloides poisoning with intravenous silibinin,” Human Toxicology, vol. 2, no. 2, pp. 183–195, 1983. View at Google Scholar · View at Scopus
  31. H. Faulstich, W. Jahn, and T. Wieland, “Silybin inhibition of amatoxin uptake in the perfused rat liver,” Drug Research, vol. 30, no. 3, pp. 452–454, 1980. View at Google Scholar · View at Scopus
  32. G. E. Sklar and M. Subramaniam, “Acetylcysteine treatment for non-acetaminophen-induced acute liver failure,” Annals of Pharmacotherapy, vol. 38, no. 3, pp. 498–501, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. L. E. Schmidt and K. Dalhoff, “Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning,” British Journal of Clinical Pharmacology, vol. 51, no. 1, pp. 87–91, 2001. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Y. K. Chan and J. A. J. H. Critchley, “Adverse reactions to intravenous N-acetylcysteine in Chinese patients with paracetamol (Acetaminophen) poisoning,” Human and Experimental Toxicology, vol. 13, no. 8, pp. 542–544, 1994. View at Google Scholar · View at Scopus
  35. J. G. O'Grady, G. J. M. Alexander, K. M. Hayllar, and R. Williams, “Early indicators of prognosis in fulminant hepatic failure,” Gastroenterology, vol. 97, no. 2, pp. 439–445, 1989. View at Google Scholar · View at Scopus
  36. J. Bernuau, “Selection for emergency liver transplantation,” Journal of Hepatology, vol. 19, no. 3, pp. 486–487, 1993. View at Google Scholar · View at Scopus
  37. M. Ganzert, N. Felgenhauer, and T. Zilker, “Indication of liver transplantation following amatoxin intoxication,” Journal of Hepatology, vol. 42, no. 2, pp. 202–209, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. L. Escudié, C. Francoz, J. P. Vinel et al., “Amanita phalloides poisoning: reassessment of prognostic factors and indications for emergency liver transplantation,” Journal of Hepatology, vol. 46, no. 3, pp. 466–473, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Bernuau, “Acute liver failure: avoidance of deleterious cofactors and early specific medical therapy for the liver are better than late intensive care for the brain,” Journal of Hepatology, vol. 41, no. 1, pp. 152–155, 2004. View at Publisher · View at Google Scholar · View at Scopus