Analysis of Extrahepatic Multiple Primary Malignancies in Patients with Hepatocellular Carcinoma according to Viral Infection Status

Table 2

Synchronous, metachronous, and multiple EHPM and viral infection status.

	HCV Ab (+)/HBs Ag (−)	HCV Ab (−)/HBs Ag (+)	HCV Ab (+)/HBs Ag (+)	HCV Ab (−)/HBs Ag (−)	Total
	n = 267 (%)	n = 65 (%)	n = 9 (%)	n = 71 (%)
Incidence of EHPM	46 (17.2)	8 (12.3)	2 (22.2)	12 (16.9)	68 (16.5)
Synchronous	8 (3.0)	3 (4.6)	1 (11.1)	6 (8.5)	18 (4.4)
Metachronous^†	38 (14.2)	5 (7.7)	1 (11.1)	5 (7.0)	49 (11.9)
Multiple EHPM	2 (0.75)	1 (1.5)	0	1 (1.4)	4 (0.97)

^†Coexisting synchronous and metachronous EHPM is categorized as metachronous.
No statistical significance was observed in distribution by viral infection status of each EHPM category.