Functional Relationships between Lipid Metabolism and Liver Regeneration

Figure 1

A metabolic model of liver regeneration: the data reviewed here implicate the metabolic response to hepatic insufficiency as a source of specific signals that initiate liver regeneration. Experimental manipulations employed to alter this metabolic response that are discussed in the text are listed in the box to the left (along with their reported effects on regeneration: suppressed, augmented, and none or variable effects). Models of fatty liver disease (FLD) in which regeneration has been assessed that are discussed in the text are listed in the box to the right. (fld: fatty liver dystrophy mouse; GRKO: glucocorticoid receptor knockout; FASKOL: liver-specific fatty acid synthase knockout mouse; L-Fabp KO: Liver fatty acid binding protein knockout; MTP-IKO: intestine-specific microsomal triglyceride transfer protein knockout; PPAR: peroxisome proliferator-activated receptor).