CYP2E1 Sensitizes the Liver to LPS- and TNF <i>α</i>-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases

<table>Scheme for activation of ASK-1 by ROS/RNS and downstream MAP kinase kinases (MKK4/7 and MKK 3/6) and MAP kinase JNK and p38 MAPK by ROS/RNS. Dissociation of the inhibitory thioredoxin (TRX) from the TRX-ASK-1 complex by ROS/RNS activates ASK-1. MKPS and MAP kinase phosphatases which deactivate activated JNK and p38 MAPK by dephosphorylation are inhibited by ROS/RNS thereby sustaining the activation of JNK and p38 MAPK.</table>

International Journal of Hepatology

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Figure 5

Figure 5: CYP2E1 Sensitizes the Liver to LPS- and TNF <i>α</i>-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases 

Figure 5 | CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases 