CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
A JNK inhibitor protects the E47 cells from loss of viability produced by TRX knockdown. The E 47 cells were incubated with and without 5 uM of the JNK inhibitor L-JNKI1for 3 hours followed by treatment with the indicated siRNA for 48 or 72 hours. (a) MTT assay to determine cell viability. (b) The effect of TRX knockdown on the activation of JNK in the absence and presence of the JNK inhibitor. Numbers under the blots refer to the pJNK/JNK ratio.
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