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International Journal of Hepatology
Volume 2012, Article ID 636392, 5 pages
http://dx.doi.org/10.1155/2012/636392
Research Article

Increased -Fetoprotein Predicts Steatosis among Patients with Chronic Hepatitis C Genotype 4

1Department of Tropical Medicine, Mansoura University, Mansoura 35516, Egypt
2Department of Internal Medicine, Mansoura University, Mansoura 35516, Egypt
3Department of Pathology, Mansoura University, Mansoura 35516, Egypt
4Department of Clinical Pathology, Mansoura University, Mansoura 35516, Egypt

Received 1 December 2011; Revised 3 February 2012; Accepted 11 March 2012

Academic Editor: Guruprasad P. Aithal

Copyright © 2012 Nasser Mousa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The prognostic importance of α-fetoprotein (AFP) level elevation in patients with chronic hepatitis C and its clinical significance in steatosis associated with HCV infection remain to be determined. The present paper assessed clinical significance of elevated AFP in patients with CHC with and without steatosis. Methods. One hundred patients with CHC were divided into 50 patients with CHC and steatosis and 50 patients with CHC and no steatosis based on liver biopsy. Results. AFP was significantly increased in CHC with steatosis than patients without steatosis ( ). Highly significant positive correlation was found between serum AFP and necroinflammation as well as the severity of fibrosis/cirrhosis and negative significant correlation with albumin level in chronic HCV with steatosis ( ) but negative nonsignificant correlation with ALT and AST level ( and ), respectively. Highly significant increase was found in chronic hepatitis patients with steatosis than CHC without steatosis regarding necroinflammation as well as the severity of fibrosis/cirrhosis and AFP ( ). Conclusion. Patients with chronic HCV and steatosis have a higher AFP levels than those without steatosis. In chronic HCV with steatosis, elevated AFP levels correlated positively with HAI and negative significant correlation with albumin level.