Review Article

Overview of Hepatocellular Adenoma in Japan

Table 2

Hepatocellular adenoma in Japan: a comparison with previous reports.

Sasaki et al., 2011 [10]*Konishi et al., 1995 [9]Lin et al., 2011 [11]Bioulac-Sage et al., 2009 [3]
( 𝑛 = 1 3 )( 𝑛 = 5 8 )( 𝑛 = 1 9 1 )( 𝑛 = 1 2 8 )

Age; mean (range)41 (15–68)3439 (5–79)41 (21–66)
Female 54%62%38%91%
Oral contraceptives29%8%4.2%78%
Alcohol >40 g/day15%ndnd12%
BMI >2515%ndnd33%
Tumor size; mean (range) (cm)5.3 (1.5–19)11.38.3 (2–31)7 (1–18)
Multiple 46%16%6%39%
Association of HCC8%2%6%4%

HNF1 𝛼 -inactivated: 15%HNF1 𝛼 -inactivated: 38%
Subtypes 𝛽 -catenin-activated: 15 nd nd 𝛽 -catenin-activated: 6%
IHCA: 39%IHCA: 52%
Unclassified: 31%Unclassified: 5%

HNF1 𝛼 : hepatocyte nuclear factor 1 𝛼 ; IHCA: inflammatory hepatocellular adenoma; BMI: body mass index; *with modification.