Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma

Table 2

Aberrant expression of eIF5A1 and eIF5A2 in different human cancers.

Malignancy	Expression in tumor		Chromosome 3q	Clinical correlation with	References
	eIF5A1	eIF5A2	amplification	high eIF5A level
Colorectal cancer	Induction	Induction	Presence	NS	[30, 47, 49]
Esophageal cancer	NS	Induction	Presence	NS	[40, 41]
Gastric cancer	NS	NS	Presence	NS	[44, 45]
Liver cancer	Unchanged	Induction	Presence	Increased number of tumor nodules,; presence of tumor venous infiltration	[37, 38, 48, 50]
Lung cancer	NS	Induction	Presence	Advanced tumor stage, poor survival of patients	[32, 43, 51]
Ovarian cancer	NS	Induction	Presence	Advanced tumor stage	[33, 46]
Pancreatic cancer	NS	Induction	Presence	NS	[36, 39, 52]
Prostate cancer	NS	NS	Presence	NS	[42]

NS: not studied.