Table of Contents Author Guidelines Submit a Manuscript
International Journal of Hepatology
Volume 2012 (2012), Article ID 853175, 9 pages
http://dx.doi.org/10.1155/2012/853175
Review Article

Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease

Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA

Received 13 September 2011; Revised 18 December 2011; Accepted 19 December 2011

Academic Editor: Laura Schrum

Copyright © 2012 Aditya Ambade and Pranoti Mandrekar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD. The key mechanisms identified so far are sensitization to gut-derived endotoxin/lipopolysaccharide resulting in proinflammatory cytokine production and cellular stress due to oxidative processes, contributing to the development and progression of disease. While oxidative stress and inflammatory responses are studied independently in ALD, mechanisms linking these two processes play a major role in pathogenesis of disease. Here we review major players of oxidative stress and inflammation and highlight signaling intermediates regulated by oxidative stress that provokes proinflammatory responses in alcoholic liver disease.