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International Journal of Hepatology
Volume 2012, Article ID 859076, 7 pages
Review Article

Biomarkers for Hepatocellular Carcinoma

1College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA
2Saint Francis Cancer Treatment Center, Grand Island, NE 68803, USA

Received 16 October 2011; Accepted 27 February 2012

Academic Editor: Neil Guha

Copyright © 2012 Tara Behne and M. Sitki Copur. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The hepatocellular carcinoma (HCC) is one of the most common malignant tumors and carries a poor survival rate. The management of patients at risk for developing HCC remains challenging. Increased understanding of cancer biology and technological advances have enabled identification of a multitude of pathological, genetic, and molecular events that drive hepatocarcinogenesis leading to discovery of numerous potential biomarkers in this disease. They are currently being aggressively evaluated to establish their value in early diagnosis, optimization of therapy, reducing the emergence of new tumors, and preventing the recurrence after surgical resection or liver transplantation. These markers not only help in prediction of prognosis or recurrence but may also assist in deciding appropriate modality of therapy and may represent novel potential targets for therapeutic interventions. In this paper, a summary of most relevant available data from published papers reporting various tissue and serum biomarkers involved in hepatocellular carcinoma was presented.