Watch the GAP: Emerging Roles for IQ Motif-Containing GTPase-Activating Proteins IQGAPs in Hepatocellular Carcinoma

Figure 1

The domain structure of human IQGAP1 and IQGAP2. CH (calponin homology) domain, WW, polyproline binding domain, IQ calmodulin-binding motif, GBD-GTPase binding domain, and RGCT-RasGAP C-terminus domain. Domain percent homology is shown. Adapted from [15, 16]. Also shown binding partners of IQGAP2 identified to date. While it has been confirmed that IQGAP2 co-immunoprecipitates with β-catenin [27], RGCT is marked as a domain responsible for β-catenin binding based on analogy with IQGAP1. A list of IQGAP1 numerous binding partners can be found in [28].