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International Journal of Hepatology
Volume 2012, Article ID 978136, 8 pages
http://dx.doi.org/10.1155/2012/978136
Research Article

Lipid Droplet Accumulation and Impaired Fat Efflux in Polarized Hepatic Cells: Consequences of Ethanol Metabolism

1Liver Study Unit-Research Service (151), VA Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, USA
2Departments of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
3Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA

Received 12 September 2011; Revised 22 November 2011; Accepted 8 December 2011

Academic Editor: Angela Dolganiuc

Copyright © 2012 Benita L. McVicker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Karuna Rasineni, and Carol A Casey, “Molecular mechanism of alcoholic fatty liver.,” Indian journal of pharmacology, vol. 44, no. 3, pp. 299–303, 2012. View at Publisher · View at Google Scholar
  • Karuna Rasineni, Benita L. McVicker, Dean J. Tuma, Mark A. McNiven, and Carol A. Casey, “Rab GTPases Associate with Isolated Lipid Droplets (LDs) and Show Altered Content After Ethanol Administration: Potential Role in Alcohol-Impaired LD Metabolism,” Alcoholism: Clinical and Experimental Research, 2013. View at Publisher · View at Google Scholar
  • Rotonya M. Carr, Giselle Peralta, Xiaoyan Yin, and Rexford S. Ahima, “Absence of Perilipin 2 Prevents Hepatic Steatosis, Glucose Intolerance and Ceramide Accumulation in Alcohol-Fed Mice,” Plos One, vol. 9, no. 5, 2014. View at Publisher · View at Google Scholar
  • Brigitte Grosse, Jeril Degrouard, Danielle Jaillard, and Doris Cassio, “Build them up and break them down,” Tissue Barriers, vol. 1, no. 4, pp. e25210, 2014. View at Publisher · View at Google Scholar
  • Yumi Imai, Michelle B. Trevino, and Rexford S. Ahima, “Lipid Droplet Proteins and Hepatic Lipid Metabolism,” Hepatic De Novo Lipogenesis and Regulation of Metabolism, pp. 165–188, 2015. View at Publisher · View at Google Scholar
  • Kavindra Kumara Wijesundera, Takeshi Izawa, Anusha Hemamali Tennakoon, Hossain M. Golbar, Miyuu Tanaka, Mitsuru Kuwamura, and Jyoji Yamate, “M1-/M2-macrophage polarization in pseudolobules consisting of adipohilin-rich hepatocytes in thioacetamide (TAA)-induced rat hepatic cirrhosis,” Experimental and Molecular Pathology, 2016. View at Publisher · View at Google Scholar
  • Giulia Vecchione, Elena Grasselli, Andrea D. Compalati, Milena Ragazzoni, Katia Cortese, Gabriella Gallo, Adriana Voci, and Laura Vergani, “Ethanol and fatty acids impair lipid homeostasis in an in vitro model of hepatic steatosis,” Food and Chemical Toxicology, 2016. View at Publisher · View at Google Scholar
  • Sathish Kumar Natarajan, Kusum K. Kharbanda, Karuna Rasineni, Murali Ganesan, Natalia A. Osna, Justin L. Mott, Dan Feng, Benita L. McVicker, Mark A. McNiven, and Carol A. Casey, “Structure, function and metabolism of hepatic and adipose tissue lipid droplets: Implications in alcoholic liver disease,” Current Molecular Pharmacology, vol. 10, no. 3, pp. 237–248, 2017. View at Publisher · View at Google Scholar
  • Karuna Rasineni, Terrence M. Donohue, Paul G. Thomes, Li Yang, Dean J. Tuma, Mark A. McNiven, and Carol A. Casey, “Ethanol-induced steatosis involves impairment of lipophagy, associated with reduced Dynamin2 activity,” Hepatology Communications, 2017. View at Publisher · View at Google Scholar
  • Micah B. Schott, Karuna Rasineni, Shaun G. Weller, Ryan J. Schulze, Arthur C. Sletten, Carol A. Casey, and Mark A. McNiven, “β-Adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure,” Journal of Biological Chemistry, vol. 292, no. 28, pp. 11815–11828, 2017. View at Publisher · View at Google Scholar
  • Ryan J. Schulze, Karuna Rasineni, Shaun G. Weller, Micah B. Schott, Barbara Schroeder, Carol A. Casey, and Mark A. McNiven, “Ethanol exposure inhibits hepatocyte lipophagy by inactivating the small guanosine triphosphatase Rab7,” Hepatology Communications, 2017. View at Publisher · View at Google Scholar
  • Simon Bucher, Arnaud Tête, Normand Podechard, Marie Liamin, Dounia Le Guillou, Martine Chevanne, Cédric Coulouarn, Muhammad Imran, Isabelle Gallais, Morgane Fernier, Quentin Hamdaoui, Marie-Anne Robin, Odile Sergent, Bernard Fromenty, and Dominique Lagadic-Gossmann, “Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo,” Scientific Reports, vol. 8, no. 1, 2018. View at Publisher · View at Google Scholar