A Reappraisal of Chemotherapy-Induced Liver Injury in Colorectal Liver Metastases before the Era of Antiangiogenics

Table 1

Baseline characteristics of the 50 included patients.

	Parameters	Total; 𝑛 (%)	Chemo+; (𝑛=33)	Chemo−; (𝑛=17)	𝑃
Demography	Age (years)	62 ± 9.3	60	63	NS
	Male gender	34 (68)	22 (66)	12 (71)	NS
	ASA score (I/II/III)	8 (16)/26 (52)/16 (32)	7/15/11	1/11/5	NS
	BMI	28 ± 4.7	27	28	NS
Comorbidities	Hypertension	21 (42)	14 (44)	7 (41)	NS
	Diabetes mellitus	4 (8)	3 (9)	1 (6)	NS
	Smoking	16 (32)	11 (33)	5 (29)	NS
	Hyperlipidemia	14 (28)	10 (30)	4 (24)	NS
Liver tests	AST (IU/L)	30.5 ± 15.2	29	33	NS
	ALT (IU/L)	31.2 ± 19	24	38	NS
	γ-Glutamyl transferase (IU/L)	86 ± 97	82	90	NS
	Alkaline phosphatase (IU/L)	110 ± 47.7	110	108	NS
	Prothrombin time (%)	89.6 ± 2.6	90.6	88.4	NS
	Total bilirubin (µmol/L)	9.2 ± 5.6	8.4	10.0	NS
	Platelets count (×10^3/mm^3)	247 ± 111	220	251	NS

ASA: anesthesiologist score association.
BMI: body mass index.
NS: not significant.